Struggling with treatment-resistant depression? Learn how Spravato vs antidepressants compares and which option might work faster for you.

Depression is a serious global issue, impacting millions and often resistant to traditional treatments. Many people turn to antidepressants, but these medications may take weeks to work.

For those who need quicker results, Spravato offers hope. This fast-acting treatment is designed specifically for treatment-resistant depression. Unlike antidepressants, it works differently and can show effects within hours.

In this blog, we’ll explore how Spravato and antidepressants compare in terms of effectiveness, safety, and speed of relief.

What Are Antidepressants, and How Do They Work?

Antidepressants are medications that balance brain chemicals like serotonin and norepinephrine to alleviate depression symptoms.

Antidepressants work by balancing brain chemicals called neurotransmitters, which affect mood, emotions, and stress responses. These medications primarily target serotonin, norepinephrine, and dopamine levels to improve communication between nerve cells. By enhancing these chemical signals, antidepressants help alleviate symptoms of depression, anxiety, and related disorders.

The most common types of antidepressants include:

  • SSRIs (Selective Serotonin Reuptake Inhibitors): These increase serotonin levels in the brain. Common examples are fluoxetine (Prozac) and sertraline (Zoloft).
  • SNRIs (Serotonin-Norepinephrine Reuptake Inhibitors): These boost serotonin and norepinephrine levels, enhancing mood and focus. Examples include venlafaxine (Effexor) and duloxetine (Cymbalta).
  • Tricyclic Antidepressants (TCAs): Older medications that affect multiple neurotransmitters but are less frequently prescribed due to their side effects.
  • MAOIs (Monoamine Oxidase Inhibitors): These prevent the breakdown of neurotransmitters but are now rarely used because of dietary restrictions and side effects.

While antidepressants are effective for many people, they require patience. It takes 4-6 weeks for most individuals to notice significant improvements. For someone amid severe depression, this wait can feel overwhelming, leading many to explore faster-acting alternatives like Spravato.

What Is Spravato, and How Is It Different from Antidepressants?

Spravato (esketamine) is a fast-acting nasal spray targeting treatment-resistant depression through unique brain pathways.

Spravato is a groundbreaking treatment specifically designed for individuals with treatment-resistant depression. Spravato works differently from traditional antidepressants by targeting NMDA receptors instead of serotonin and norepinephrine. This process affects glutamate, a key neurotransmitter in mood regulation and cognitive function.

The U.S. Food and Drug Administration (FDA) approved Spravato in 2019 as a treatment for adults who haven’t responded to at least two other antidepressant therapies. This approval marked progress for treatment-resistant cases, bringing hope to those with limited options.

What sets Spravato apart is its rapid action. While most antidepressants take weeks to show results, Spravato can reduce symptoms within hours. Its unique mechanism also makes it a valuable option for individuals experiencing severe depressive episodes or suicidal thoughts, as it works quickly to alleviate symptoms.

What Are the Key Differences Between Spravato and Antidepressants?

Spravato works through NMDA receptor modulation, while antidepressants alter serotonin and norepinephrine levels.

When comparing Spravato vs antidepressants, there are significant differences in how they are administered, how they work, and their accessibility. These differences are key to choosing the right depression treatment.

Administration

The method of administration is one of the most noticeable differences between Spravato vs antidepressants:

  • Spravato: Delivered as a nasal spray and always administered in a medical clinic under supervision. This ensures patient safety.
  • Antidepressants: Taken as oral pills, typically once daily, which can be used at home without medical supervision.

While antidepressants offer convenience for daily use, Spravato requires scheduled clinic visits, which may be challenging for some patients but ensures professional monitoring.

Mechanism of Action

Both treatments work through different pathways to address depression symptoms:

  • Spravato: Targets NMDA receptors in the brain and modulates glutamate, a neurotransmitter essential for brain cell communication. This approach helps repair neural connections damaged by chronic depression and provides rapid symptom relief.
  • Antidepressants: Work by increasing serotonin, norepinephrine, and dopamine levels. These neurotransmitters regulate mood and emotional well-being over time, gradually reducing depressive symptoms.

Onset of Relief

The speed at which symptoms improve is a major consideration when choosing antidepressants  vs Spravato:

  • Spravato: Relief often begins within hours or a few days, making it ideal for those needing immediate improvement.
  • Antidepressants: Typically take 4-6 weeks to show noticeable effects, with some patients waiting even longer for significant changes.

For individuals experiencing severe or treatment-resistant depression, Spravato offers a quicker path to relief compared to traditional antidepressants.

Cost and Insurance Considerations

The cost of treatment and insurance coverage can significantly influence the decision between antidepressants vs Spravato:

  • Spravato: Costs are higher due to the need for in-clinic administration and specialized monitoring. However, most insurance plans cover Spravato for patients with treatment-resistant depression. Financial assistance programs are also available.
  • Antidepressants: Generally affordable, especially generic options. They are widely covered by insurance plans, making them more accessible for most patients.

While Spravato requires a higher upfront investment, the potential for rapid and effective relief makes it worthwhile for eligible patients.

Why Choose Spravato Over Antidepressants?

Antidepressants vs Spravato comes down to individual needs and circumstances. Spravato is often chosen when:

  • A patient has tried at least two antidepressants without success.
  • Immediate relief from severe depressive symptoms is critical.
  • A patient prefers a novel approach targeting brain pathways beyond serotonin and norepinephrine.

Does Spravato Work Faster Than Antidepressants?

Yes, Spravato often provides symptom relief within hours, unlike antidepressants, which may take weeks.

For individuals facing severe or treatment-resistant depression, the speed of symptom relief can significantly impact their quality of life. When comparing antidepressants vs Spravato, the most notable difference is the time it takes for each treatment to show results.

Onset Time for Spravato

Clinical studies show that Spravato (esketamine) delivers rapid symptom relief, often within hours to days. This makes it especially valuable for individuals with urgent needs, such as those experiencing suicidal ideation.

  • Patients using Spravato often report noticeable improvements within 24 hours of treatment.
  • Its fast action is linked to its unique mechanism of modulating NMDA receptors and boosting glutamate levels.
  • Spravato’s rapid onset helps improve mood quickly, making it a breakthrough for treatment-resistant cases.

Onset Time for Antidepressants

In contrast, traditional antidepressants require a longer time to work, as they gradually balance neurotransmitter levels in the brain.

  • Most antidepressants take 4-6 weeks to show significant improvements in mood and symptoms.
  • Some patients may need adjustments in dosage or medication type, further delaying relief.
  • The slow onset can be challenging for individuals with severe depression who need immediate symptom improvement.

What Are the Common Side Effects of Spravato vs Antidepressants?

Spravato may cause dissociation and dizziness, while antidepressants commonly cause nausea and fatigue.

Both Spravato and antidepressants are effective treatments for depression, but they come with their own sets of side effects. Understanding this helps patients choose the right treatment.

Side Effects of Spravato

Spravato, a nasal spray administered under medical supervision, has side effects primarily related to its unique mechanism and rapid action.

  • Dissociation: Patients may feel disconnected from their thoughts or surroundings temporarily.
  • Dizziness: Some individuals report lightheadedness after administration.
  • Elevated Blood Pressure: A temporary increase in blood pressure may occur, requiring monitoring during the session.
  • Nausea: Mild nausea is common but typically subsides quickly.
  • Sedation: Some patients may feel drowsy or need to rest post-treatment.

Side Effects of Antidepressants

Traditional antidepressants, taken as oral pills, also have side effects that vary depending on the medication type and individual response.

  • Nausea: A common early side effect that usually improves with continued use.
  • Fatigue: Many patients report tiredness, especially during the first few weeks.
  • Sexual Dysfunction: Decreased libido or difficulty achieving orgasm is frequent with SSRIs and SNRIs.
  • Weight Gain: Some antidepressants may increase appetite and gradual weight gain.
  • Dry Mouth: A frequent side effect, especially with older medications like tricyclic antidepressants.

Comparing Side Effects

When evaluating Spravato vs antidepressants, the choice often depends on tolerance to side effects and the need for supervision:

  • Spravato: Side effects like dissociation and dizziness are temporary and managed in a clinical setting. This ensures patient safety but requires regular in-clinic visits.
  • Antidepressants: Side effects such as nausea, fatigue, and weight gain are more prolonged but can often be managed through dose adjustments.

Who Is a Better Candidate for Spravato vs Antidepressants?

Spravato is ideal for treatment-resistant depression, while antidepressants are suitable for most mild to moderate cases.

When choosing between Spravato and antidepressants, the decision depends on the severity of depression, treatment history, and individual needs. Understanding who benefits most from each option can help guide treatment plans.

Criteria for Spravato Candidates

Spravato is specifically designed for individuals with treatment-resistant depression. These patients typically meet the following criteria:

  • Failed Two or More Antidepressants: Patients who haven’t responded to at least two antidepressants at adequate doses are considered for Spravato.
  • Severe Depression Symptoms: Spravato is often used for cases of severe or debilitating depression, including those accompanied by suicidal thoughts.
  • Need for Rapid Relief: Ideal for individuals requiring immediate symptom improvement due to critical circumstances.
  • Eligibility for Supervised Treatment: Candidates must be able to attend in-clinic sessions, as Spravato requires medical monitoring during administration.

Who Benefits Most from Antidepressants?

Antidepressants are a first-line treatment option for many people with depression. They are suitable for individuals who:

  • Have Mild to Moderate Depression: Most patients with manageable symptoms find relief with antidepressants.
  • Can Tolerate Gradual Improvements: Antidepressants work over 4-6 weeks, making them a good fit for those who don’t need immediate results.
  • Require Convenient Treatment: Oral pills allow for independent use at home, fitting easily into daily routines.
  • Have Coexisting Conditions: Certain antidepressants also help with anxiety, OCD, or chronic pain, making them versatile for multiple mental health conditions.

Spravato vs Antidepressants: Which Is Right for You?

Choosing between Spravato and antidepressants depends on individual circumstances:

Choose Spravato If:

  • You have tried multiple antidepressants without success.
  • You need fast-acting relief from severe depression.
  • You can commit to in-clinic treatment sessions.

Choose Antidepressants If:

  • Your symptoms are mild to moderate and manageable over time.
  • You prefer the convenience of home-based medication.
  • You need treatment for both depression and other conditions, like anxiety.

FAQs

Is Spravato more effective than traditional antidepressants?

Spravato is more effective for treatment-resistant depression, offering rapid relief where traditional antidepressants often fail.

How long does Spravato treatment take?

Each Spravato session lasts about two hours, including monitoring time after administering the nasal spray.

Can Spravato replace antidepressants entirely?

Spravato is usually used alongside an oral antidepressant and not as a complete replacement for traditional treatments.

Are there long-term risks with using Spravato?

Spravato’s long-term risks are minimal when administered under medical supervision, but patients are monitored for side effects.

Does insurance cover Spravato?

Most insurance plans cover Spravato for eligible patients with treatment-resistant depression, but coverage details vary.

Best Spravato treatment by professionals at Contemporary Care

Transforming Mental Health Care at Contemporary Care Centers

Contemporary Care Centers is dedicated to providing innovative and compassionate mental health services tailored to each individual’s needs. We offer advanced treatments and a patient-focused approach to help you reclaim your mental well-being. Here’s an overview of the services we offer:

Our Services

  • Spravato (Esketamine) Therapy: Spravato, a breakthrough for treatment-resistant depression, offers rapid relief under medical supervision for those unresponsive to traditional medications.
  • Transcranial Magnetic Stimulation (TMS) Therapy: A non-invasive, drug-free treatment for depression and other mental health conditions. TMS uses magnetic pulses to stimulate brain regions associated with mood regulation.
  • Medication Management: Our expert providers assess your unique needs and create personalized medication plans to ensure the best possible outcomes.
  • Psychotherapy Services: We offer counseling and talk therapy sessions to help you navigate life’s challenges, manage stress, and improve emotional resilience.
  • Comprehensive Mental Health Evaluations: Our detailed assessments help diagnose conditions like anxiety, depression, and ADHD to design the most effective treatment plan.

Your Journey to Better Mental Health Starts Here

At Contemporary Care Centers, we combine cutting-edge treatments with compassionate care to empower you on your path to recovery.Ready to take the first step? Call us today or visit our website to schedule your consultation. Together, we’ll create a personalized treatment plan that helps you thrive.